Risk compensation after HIV-1 vaccination may accelerate viral adaptation and reduce cost-effectiveness: a modeling study

Abstract Pathogen populations can evolve in response to selective pressure from vaccine-induced immune responses. For HIV, models predict that viral adaptation, either via strain replacement or selection on de novo mutation, may rapidly reduce the effectiveness of an HIV vaccine. We hypothesized tha...

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Autores principales: Kathryn Peebles, John E. Mittler, Steven M. Goodreau, James T. Murphy, Molly C. Reid, Neil Abernethy, Geoffrey S. Gottlieb, Ruanne V. Barnabas, Joshua T. Herbeck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bce81ff0a8e8480b8372dd88288e5978
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