Assembling custom side chains on proteoglycans to interrogate their function in living cells

Currently, it is not possible to generate proteoglycans displaying glycosaminoglycan chains with specific structures. Here the authors show that by using an aldehyde tag-based methodology it is possible to insert these specific chains onto proteoglycans expressed on the cell surface.

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Autores principales:	Wenshuang Wang, Naihan Han, Yingying Xu, Yunxue Zhao, Liran Shi, Jorge Filmus, Fuchuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd135f511def4709b023984758718989
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spelling	oai:doaj.org-article:bd135f511def4709b0239847587189892021-12-02T14:40:50ZAssembling custom side chains on proteoglycans to interrogate their function in living cells10.1038/s41467-020-19765-y2041-1723https://doaj.org/article/bd135f511def4709b0239847587189892020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19765-yhttps://doaj.org/toc/2041-1723Currently, it is not possible to generate proteoglycans displaying glycosaminoglycan chains with specific structures. Here the authors show that by using an aldehyde tag-based methodology it is possible to insert these specific chains onto proteoglycans expressed on the cell surface.Wenshuang WangNaihan HanYingying XuYunxue ZhaoLiran ShiJorge FilmusFuchuan LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenshuang Wang Naihan Han Yingying Xu Yunxue Zhao Liran Shi Jorge Filmus Fuchuan Li Assembling custom side chains on proteoglycans to interrogate their function in living cells
description	Currently, it is not possible to generate proteoglycans displaying glycosaminoglycan chains with specific structures. Here the authors show that by using an aldehyde tag-based methodology it is possible to insert these specific chains onto proteoglycans expressed on the cell surface.
format	article
author	Wenshuang Wang Naihan Han Yingying Xu Yunxue Zhao Liran Shi Jorge Filmus Fuchuan Li
author_facet	Wenshuang Wang Naihan Han Yingying Xu Yunxue Zhao Liran Shi Jorge Filmus Fuchuan Li
author_sort	Wenshuang Wang
title	Assembling custom side chains on proteoglycans to interrogate their function in living cells
title_short	Assembling custom side chains on proteoglycans to interrogate their function in living cells
title_full	Assembling custom side chains on proteoglycans to interrogate their function in living cells
title_fullStr	Assembling custom side chains on proteoglycans to interrogate their function in living cells
title_full_unstemmed	Assembling custom side chains on proteoglycans to interrogate their function in living cells
title_sort	assembling custom side chains on proteoglycans to interrogate their function in living cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bd135f511def4709b023984758718989
work_keys_str_mv	AT wenshuangwang assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT naihanhan assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT yingyingxu assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT yunxuezhao assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT liranshi assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT jorgefilmus assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells AT fuchuanli assemblingcustomsidechainsonproteoglycanstointerrogatetheirfunctioninlivingcells
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Assembling custom side chains on proteoglycans to interrogate their function in living cells

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