Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.

Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.

In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which uniquely exhibits minimal intergenerational instability. We also report the first identification of the R6/2 transgene insertion site. The relativel...

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Autores principales: Randi-Michelle Cowin, Nghiem Bui, Deanna Graham, Jennie R Green, Stephan Grueninger, Lisa A Yuva-Paylor, Arsalan U Syed, Andreas Weiss, Richard Paylor
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/bd5678873d0346399ed7e86622ea635b
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https://doaj.org/article/bd5678873d0346399ed7e86622ea635b

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