Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA

Base editors are double-strand-break (DSB)-free genome editing tools and have been widely used in diverse living systems. However, it is reported that these tools can cause substantial off-target editing.

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Autores principales:	Zhiwei Hu, Yannan Wang, Qian Liu, Yan Qiu, Zhiyu Zhong, Kangdi Li, Wenhua Li, Zixin Deng, Yuhui Sun
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/bdac9787d38e4570b75d966420a1da21
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spelling	oai:doaj.org-article:bdac9787d38e4570b75d966420a1da212021-11-03T18:56:09ZImproving the Precision of Base Editing by Bubble Hairpin Single Guide RNA2150-751110.1128/mBio.00342-21https://doaj.org/article/bdac9787d38e4570b75d966420a1da212021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00342-21https://doaj.org/toc/2150-7511 Base editors are double-strand-break (DSB)-free genome editing tools and have been widely used in diverse living systems. However, it is reported that these tools can cause substantial off-target editing.Zhiwei HuYannan WangQian LiuYan QiuZhiyu ZhongKangdi LiWenhua LiZixin DengYuhui SunAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Zhiwei Hu Yannan Wang Qian Liu Yan Qiu Zhiyu Zhong Kangdi Li Wenhua Li Zixin Deng Yuhui Sun Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
description	Base editors are double-strand-break (DSB)-free genome editing tools and have been widely used in diverse living systems. However, it is reported that these tools can cause substantial off-target editing.
format	article
author	Zhiwei Hu Yannan Wang Qian Liu Yan Qiu Zhiyu Zhong Kangdi Li Wenhua Li Zixin Deng Yuhui Sun
author_facet	Zhiwei Hu Yannan Wang Qian Liu Yan Qiu Zhiyu Zhong Kangdi Li Wenhua Li Zixin Deng Yuhui Sun
author_sort	Zhiwei Hu
title	Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
title_short	Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
title_full	Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
title_fullStr	Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
title_full_unstemmed	Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA
title_sort	improving the precision of base editing by bubble hairpin single guide rna
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/bdac9787d38e4570b75d966420a1da21
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Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA

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