Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions

Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing...

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Autores principales: Hyunjin Jung, Seong-Wook Kim, Minsoo Kim, Jongryul Hong, Daseuli Yu, Ji Hye Kim, Yunju Lee, Sungsoo Kim, Doyeon Woo, Hee-Sup Shin, Byung Ouk Park, Won Do Heo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bdb35816507e4ab195f71dcd83e79b7e
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Sumario:Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.