IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation

Clearance of apoptotic neutrophils by macrophages is important for the resolution of inflammation. Here, the authors show that interferon-β produced by resolution phase macrophages promotes neutrophil apoptosis and efferocytosis and induces macrophage reprogramming to a pro-resolving phenotype, ther...

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Autores principales: Senthil Kumaran Satyanarayanan, Driss El Kebir, Soaad Soboh, Sergei Butenko, Meriem Sekheri, Janan Saadi, Neta Peled, Simaan Assi, Amira Othman, Sagie Schif-Zuck, Yonatan Feuermann, Dalit Barkan, Noa Sher, János G. Filep, Amiram Ariel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bde7b79a24f74c988fe97e64005be189
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spelling oai:doaj.org-article:bde7b79a24f74c988fe97e64005be1892021-12-02T15:36:23ZIFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation10.1038/s41467-019-10903-92041-1723https://doaj.org/article/bde7b79a24f74c988fe97e64005be1892019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10903-9https://doaj.org/toc/2041-1723Clearance of apoptotic neutrophils by macrophages is important for the resolution of inflammation. Here, the authors show that interferon-β produced by resolution phase macrophages promotes neutrophil apoptosis and efferocytosis and induces macrophage reprogramming to a pro-resolving phenotype, thereby identifying IFN-β as a multi-pronged pro-resolution cytokine.Senthil Kumaran SatyanarayananDriss El KebirSoaad SobohSergei ButenkoMeriem SekheriJanan SaadiNeta PeledSimaan AssiAmira OthmanSagie Schif-ZuckYonatan FeuermannDalit BarkanNoa SherJános G. FilepAmiram ArielNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Senthil Kumaran Satyanarayanan
Driss El Kebir
Soaad Soboh
Sergei Butenko
Meriem Sekheri
Janan Saadi
Neta Peled
Simaan Assi
Amira Othman
Sagie Schif-Zuck
Yonatan Feuermann
Dalit Barkan
Noa Sher
János G. Filep
Amiram Ariel
IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
description Clearance of apoptotic neutrophils by macrophages is important for the resolution of inflammation. Here, the authors show that interferon-β produced by resolution phase macrophages promotes neutrophil apoptosis and efferocytosis and induces macrophage reprogramming to a pro-resolving phenotype, thereby identifying IFN-β as a multi-pronged pro-resolution cytokine.
format article
author Senthil Kumaran Satyanarayanan
Driss El Kebir
Soaad Soboh
Sergei Butenko
Meriem Sekheri
Janan Saadi
Neta Peled
Simaan Assi
Amira Othman
Sagie Schif-Zuck
Yonatan Feuermann
Dalit Barkan
Noa Sher
János G. Filep
Amiram Ariel
author_facet Senthil Kumaran Satyanarayanan
Driss El Kebir
Soaad Soboh
Sergei Butenko
Meriem Sekheri
Janan Saadi
Neta Peled
Simaan Assi
Amira Othman
Sagie Schif-Zuck
Yonatan Feuermann
Dalit Barkan
Noa Sher
János G. Filep
Amiram Ariel
author_sort Senthil Kumaran Satyanarayanan
title IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
title_short IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
title_full IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
title_fullStr IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
title_full_unstemmed IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
title_sort ifn-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/bde7b79a24f74c988fe97e64005be189
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