A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expres...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nadeene E Riddick, Emilia A Hermann, Lamorris M Loftin, Sarah T Elliott, Winston C Wey, Barbara Cervasi, Jessica Taaffe, Jessica C Engram, Bing Li, James G Else, Yingying Li, Beatrice H Hahn, Cynthia A Derdeyn, Donald L Sodora, Cristian Apetrei, Mirko Paiardini, Guido Silvestri, Ronald G Collman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/bdfa60bc81c34578a055ec162df9a0c6
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/bdfa60bc81c34578a055ec162df9a0c6

Ejemplares similares