C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes

In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal and soil bacteria, biochemically characterise them a...

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Autores principales:	Takahiro Mori, Takuto Kumano, Haibing He, Satomi Watanabe, Miki Senda, Toshio Moriya, Naruhiko Adachi, Sanae Hori, Yuzu Terashita, Masato Kawasaki, Yoshiteru Hashimoto, Takayoshi Awakawa, Toshiya Senda, Ikuro Abe, Michihiko Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/be2834e7f7604e8f81be75ba24bda5b8
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spelling	oai:doaj.org-article:be2834e7f7604e8f81be75ba24bda5b82021-11-08T11:11:47ZC-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes10.1038/s41467-021-26585-12041-1723https://doaj.org/article/be2834e7f7604e8f81be75ba24bda5b82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26585-1https://doaj.org/toc/2041-1723In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal and soil bacteria, biochemically characterise them and determine their structures and probe catalytic important residues in mutagenesis experiments.Takahiro MoriTakuto KumanoHaibing HeSatomi WatanabeMiki SendaToshio MoriyaNaruhiko AdachiSanae HoriYuzu TerashitaMasato KawasakiYoshiteru HashimotoTakayoshi AwakawaToshiya SendaIkuro AbeMichihiko KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Mori Takuto Kumano Haibing He Satomi Watanabe Miki Senda Toshio Moriya Naruhiko Adachi Sanae Hori Yuzu Terashita Masato Kawasaki Yoshiteru Hashimoto Takayoshi Awakawa Toshiya Senda Ikuro Abe Michihiko Kobayashi C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
description	In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal and soil bacteria, biochemically characterise them and determine their structures and probe catalytic important residues in mutagenesis experiments.
format	article
author	Takahiro Mori Takuto Kumano Haibing He Satomi Watanabe Miki Senda Toshio Moriya Naruhiko Adachi Sanae Hori Yuzu Terashita Masato Kawasaki Yoshiteru Hashimoto Takayoshi Awakawa Toshiya Senda Ikuro Abe Michihiko Kobayashi
author_facet	Takahiro Mori Takuto Kumano Haibing He Satomi Watanabe Miki Senda Toshio Moriya Naruhiko Adachi Sanae Hori Yuzu Terashita Masato Kawasaki Yoshiteru Hashimoto Takayoshi Awakawa Toshiya Senda Ikuro Abe Michihiko Kobayashi
author_sort	Takahiro Mori
title	C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
title_short	C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
title_full	C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
title_fullStr	C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
title_full_unstemmed	C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
title_sort	c-glycoside metabolism in the gut and in nature: identification, characterization, structural analyses and distribution of c-c bond-cleaving enzymes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/be2834e7f7604e8f81be75ba24bda5b8
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C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes

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