SAMase of Bacteriophage T3 Inactivates <named-content content-type="genus-species">Escherichia coli</named-content>’s Methionine <italic toggle="yes">S</italic>-Adenosyltransferase by Forming Heteropolymers

SAMase of Bacteriophage T3 Inactivates <named-content content-type="genus-species">Escherichia coli</named-content>’s Methionine <italic toggle="yes">S</italic>-Adenosyltransferase by Forming Heteropolymers

ABSTRACT S-Adenosylmethionine lyase (SAMase) of bacteriophage T3 degrades the intracellular SAM pools of the host Escherichia coli cells, thereby inactivating a crucial metabolite involved in a plethora of cellular functions, including DNA methylation. SAMase is the first viral protein expressed upo...

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Autores principales: Hadas Simon-Baram, Daniel Kleiner, Fannia Shmulevich, Raz Zarivach, Ran Zalk, Huayuan Tang, Feng Ding, Shimon Bershtein
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
enzyme filamentation
metabolic regulation
virus-host interaction
cryo-EM
molecular dynamics (MD) simulations
bacteriophage T3
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/be476d645fd647cc9eb61ed1f2985f7c
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https://doaj.org/article/be476d645fd647cc9eb61ed1f2985f7c

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