Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations.

Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations.

<h4>Background</h4>In eukaryotes the genetic material is enclosed by a continuous membrane system, the nuclear envelope (NE). Along the NE specific proteins assemble to form meshworks and mutations in these proteins have been described in a group of human diseases called laminopathies. L...

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Autores principales: Liu Yang, Martina Munck, Karthic Swaminathan, Larisa E Kapinos, Angelika A Noegel, Sascha Neumann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/be5a7a7122af45e9837089214e80377f
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