A Novel Combined Conjugate Therapeutic Cancer Vaccine, Recombinant EGF-CRM197, in Patients With Advanced Solid Tumors: A Phase I Clinical Study

IntroductionThe therapeutic cancer vaccine recombinant Epidermal Growth Factor (EGF)-CRM197 is a novel combined conjugate EGF with CRM197 as a carrier protein. Immunization with the EGF-CRM197 vaccine can induce high levels of neutralizing anti-EGF antibodies that inhibit EGF/EGFR signaling and ther...

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Autores principales: An-Wen Xiong, Jue-Min Fang, Sheng-Xiang Ren, Wei Li, Jing Wang, Yu Zhao, Guo-You Chen, Qing Xu, Cai-Cun Zhou
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/be846440cbd8444a941e546a2d628629
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