NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice...

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Autores principales:	Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bed4a8bce0a947e6b296d8080b0074aa
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spelling	oai:doaj.org-article:bed4a8bce0a947e6b296d8080b0074aa2021-12-02T17:31:18ZNRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells10.1038/ncomms131032041-1723https://doaj.org/article/bed4a8bce0a947e6b296d8080b0074aa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13103https://doaj.org/toc/2041-1723Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.Joanna RatajczakMagali JoffraudSamuel A. J. TrammellRosa RasNúria CanelaMarie BoutantSameer S. KulkarniMarcelo RodriguesPhilip RedpathMarie E. MigaudJohan AuwerxOscar YanesCharles BrennerCarles CantóNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanna Ratajczak Magali Joffraud Samuel A. J. Trammell Rosa Ras Núria Canela Marie Boutant Sameer S. Kulkarni Marcelo Rodrigues Philip Redpath Marie E. Migaud Johan Auwerx Oscar Yanes Charles Brenner Carles Cantó NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
description	Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.
format	article
author	Joanna Ratajczak Magali Joffraud Samuel A. J. Trammell Rosa Ras Núria Canela Marie Boutant Sameer S. Kulkarni Marcelo Rodrigues Philip Redpath Marie E. Migaud Johan Auwerx Oscar Yanes Charles Brenner Carles Cantó
author_facet	Joanna Ratajczak Magali Joffraud Samuel A. J. Trammell Rosa Ras Núria Canela Marie Boutant Sameer S. Kulkarni Marcelo Rodrigues Philip Redpath Marie E. Migaud Johan Auwerx Oscar Yanes Charles Brenner Carles Cantó
author_sort	Joanna Ratajczak
title	NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
title_short	NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
title_full	NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
title_fullStr	NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
title_full_unstemmed	NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
title_sort	nrk1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bed4a8bce0a947e6b296d8080b0074aa
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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

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