Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response

High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance. Here, the authors through a systematic analysis of proteomic and drug response data of 14 HGS-OvCa PDXs demonstrate that targeting apoptosis regulators can improve response of these tumors to inhibitors of the P...

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Main Authors: Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills, Joan S. Brugge
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/bef99f7f9cf545ffab161533fef245e3
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