Ex vivo visualization of RNA polymerase III-specific gene activity with electron microscopy

Manger, Ermel, and Frangakis report the use of CRISPR/Cas9 to stably insert multiple copies of a particular gene-of-interest near the 35S rRNA gene, to allow direct visualization of gene clusters with electron microscopy. They achieve more than 7-fold enrichment of associated Pol III complexes withi...

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Autores principales: Sina Manger, Utz H. Ermel, Achilleas S. Frangakis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bf196ee91b9141eaaa696f911e1f0986
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