Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

NEMO is a member of the IKK complex that binds ubiquitin, involved in NF-κB signalling and proposed to form higher order structures. Here the authors use super-resolution microscopy to detect the presence of NEMO lattices in cells, that are modified by NF-κB treatment and abrogated by mutations affe...

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Autores principales:	Janine Scholefield, Ricardo Henriques, Anca F. Savulescu, Elisabeth Fontan, Alix Boucharlat, Emmanuel Laplantine, Asma Smahi, Alain Israël, Fabrice Agou, Musa M. Mhlanga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf1e75c472b84f6aaf2453cc4cab9d72
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spelling	oai:doaj.org-article:bf1e75c472b84f6aaf2453cc4cab9d722021-12-02T17:31:31ZSuper-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti10.1038/ncomms126292041-1723https://doaj.org/article/bf1e75c472b84f6aaf2453cc4cab9d722016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12629https://doaj.org/toc/2041-1723NEMO is a member of the IKK complex that binds ubiquitin, involved in NF-κB signalling and proposed to form higher order structures. Here the authors use super-resolution microscopy to detect the presence of NEMO lattices in cells, that are modified by NF-κB treatment and abrogated by mutations affecting NEMO ubiquitin binding.Janine ScholefieldRicardo HenriquesAnca F. SavulescuElisabeth FontanAlix BoucharlatEmmanuel LaplantineAsma SmahiAlain IsraëlFabrice AgouMusa M. MhlangaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janine Scholefield Ricardo Henriques Anca F. Savulescu Elisabeth Fontan Alix Boucharlat Emmanuel Laplantine Asma Smahi Alain Israël Fabrice Agou Musa M. Mhlanga Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
description	NEMO is a member of the IKK complex that binds ubiquitin, involved in NF-κB signalling and proposed to form higher order structures. Here the authors use super-resolution microscopy to detect the presence of NEMO lattices in cells, that are modified by NF-κB treatment and abrogated by mutations affecting NEMO ubiquitin binding.
format	article
author	Janine Scholefield Ricardo Henriques Anca F. Savulescu Elisabeth Fontan Alix Boucharlat Emmanuel Laplantine Asma Smahi Alain Israël Fabrice Agou Musa M. Mhlanga
author_facet	Janine Scholefield Ricardo Henriques Anca F. Savulescu Elisabeth Fontan Alix Boucharlat Emmanuel Laplantine Asma Smahi Alain Israël Fabrice Agou Musa M. Mhlanga
author_sort	Janine Scholefield
title	Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
title_short	Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
title_full	Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
title_fullStr	Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
title_full_unstemmed	Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti
title_sort	super-resolution microscopy reveals a preformed nemo lattice structure that is collapsed in incontinentia pigmenti
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bf1e75c472b84f6aaf2453cc4cab9d72
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Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

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