Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

Integrin β2 attachment regulates inflammation via effects on neutrophil rolling and extravasation through sequential integrin extension then headpiece opening. Here the authors show an alternative open headpiece prior to extension stabilized in cisby ICAM-1 that limits neutrophil adhesion.

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Autores principales:	Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf21e777e3c842518d89e822f46d2e45
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spelling	oai:doaj.org-article:bf21e777e3c842518d89e822f46d2e452021-12-02T15:35:21ZNeutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis10.1038/ncomms126582041-1723https://doaj.org/article/bf21e777e3c842518d89e822f46d2e452016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12658https://doaj.org/toc/2041-1723Integrin β2 attachment regulates inflammation via effects on neutrophil rolling and extravasation through sequential integrin extension then headpiece opening. Here the authors show an alternative open headpiece prior to extension stabilized in cisby ICAM-1 that limits neutrophil adhesion.Zhichao FanSara McArdleAlex MarkiZbigniew MikulskiEdgar GutierrezBritta EngelhardtUrban DeutschMark GinsbergAlex GroismanKlaus LeyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhichao Fan Sara McArdle Alex Marki Zbigniew Mikulski Edgar Gutierrez Britta Engelhardt Urban Deutsch Mark Ginsberg Alex Groisman Klaus Ley Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
description	Integrin β2 attachment regulates inflammation via effects on neutrophil rolling and extravasation through sequential integrin extension then headpiece opening. Here the authors show an alternative open headpiece prior to extension stabilized in cisby ICAM-1 that limits neutrophil adhesion.
format	article
author	Zhichao Fan Sara McArdle Alex Marki Zbigniew Mikulski Edgar Gutierrez Britta Engelhardt Urban Deutsch Mark Ginsberg Alex Groisman Klaus Ley
author_facet	Zhichao Fan Sara McArdle Alex Marki Zbigniew Mikulski Edgar Gutierrez Britta Engelhardt Urban Deutsch Mark Ginsberg Alex Groisman Klaus Ley
author_sort	Zhichao Fan
title	Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
title_short	Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
title_full	Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
title_fullStr	Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
title_full_unstemmed	Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
title_sort	neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bf21e777e3c842518d89e822f46d2e45
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Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis

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