A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models

Abstract E26 avian leukemia oncogene 2, 3′ domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2 db1/db1 ), which lacks the DNA-binding domain, was previously reported to exhibit embryonic lethality caused by a trophoblast abnormality. This phenotype could be...

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Autores principales: Yuki Kishimoto, Iori Nishiura, Wataru Hirata, Shunsuke Yuri, Nami Yamamoto, Masahito Ikawa, Ayako Isotani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bf2a49bdc5ea49c39fd1d3c319f5043a
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