Structural basis to stabilize the domain motion of BARD1-ARD BRCT by CstF50

Abstract BRCA1 associated ring domain protein 1(BARD1) is a tumor suppressor protein having a wide role in cellular processes like cell-cycle checkpoint, DNA damage repair and maintenance of genomic integrity. Germ-line mutation Gln 564 His discovered in linker region of BARD1 leads to loss of bindi...

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Auteurs principaux: Rajan Kumar Choudhary, Mohd Quadir Siddiqui, Pankaj S. Thapa, Nikhil Gadewal, Senthil Kumar Nachimuthu, Ashok K. Varma
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/bf40bf00aad3482ab15109c7ad448f44
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