Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating memb...

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Autores principales: Zhiguang Jia, Jianhan Chen
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c
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spelling oai:doaj.org-article:bf4f8b3a1dbc4a51bb8c8b7646a0653c2021-12-02T15:52:58ZSpecific PIP2 binding promotes calcium activation of TMEM16A chloride channels10.1038/s42003-021-01782-22399-3642https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01782-2https://doaj.org/toc/2399-3642Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating membrane-associated proteins.Zhiguang JiaJianhan ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Zhiguang Jia
Jianhan Chen
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
description Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating membrane-associated proteins.
format article
author Zhiguang Jia
Jianhan Chen
author_facet Zhiguang Jia
Jianhan Chen
author_sort Zhiguang Jia
title Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
title_short Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
title_full Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
title_fullStr Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
title_full_unstemmed Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
title_sort specific pip2 binding promotes calcium activation of tmem16a chloride channels
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c
work_keys_str_mv AT zhiguangjia specificpip2bindingpromotescalciumactivationoftmem16achloridechannels
AT jianhanchen specificpip2bindingpromotescalciumactivationoftmem16achloridechannels
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