Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels
Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating memb...
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Nature Portfolio
2021
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oai:doaj.org-article:bf4f8b3a1dbc4a51bb8c8b7646a0653c2021-12-02T15:52:58ZSpecific PIP2 binding promotes calcium activation of TMEM16A chloride channels10.1038/s42003-021-01782-22399-3642https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01782-2https://doaj.org/toc/2399-3642Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating membrane-associated proteins.Zhiguang JiaJianhan ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021) |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Zhiguang Jia Jianhan Chen Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
description |
Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating membrane-associated proteins. |
format |
article |
author |
Zhiguang Jia Jianhan Chen |
author_facet |
Zhiguang Jia Jianhan Chen |
author_sort |
Zhiguang Jia |
title |
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
title_short |
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
title_full |
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
title_fullStr |
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
title_full_unstemmed |
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels |
title_sort |
specific pip2 binding promotes calcium activation of tmem16a chloride channels |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c |
work_keys_str_mv |
AT zhiguangjia specificpip2bindingpromotescalciumactivationoftmem16achloridechannels AT jianhanchen specificpip2bindingpromotescalciumactivationoftmem16achloridechannels |
_version_ |
1718385534078812160 |