Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.

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Auteurs principaux: Zuanning Yuan, Roxana Georgescu, Grant D. Schauer, Michael E. O’Donnell, Huilin Li
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/bf5369f5dc0e4ac5973ac7d20dc7daaf
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