Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.

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Autores principales:	Zuanning Yuan, Roxana Georgescu, Grant D. Schauer, Michael E. O’Donnell, Huilin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf5369f5dc0e4ac5973ac7d20dc7daaf
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spelling	oai:doaj.org-article:bf5369f5dc0e4ac5973ac7d20dc7daaf2021-12-02T18:02:42ZStructure of the polymerase ε holoenzyme and atomic model of the leading strand replisome10.1038/s41467-020-16910-52041-1723https://doaj.org/article/bf5369f5dc0e4ac5973ac7d20dc7daaf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16910-5https://doaj.org/toc/2041-1723DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.Zuanning YuanRoxana GeorgescuGrant D. SchauerMichael E. O’DonnellHuilin LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zuanning Yuan Roxana Georgescu Grant D. Schauer Michael E. O’Donnell Huilin Li Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
description	DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.
format	article
author	Zuanning Yuan Roxana Georgescu Grant D. Schauer Michael E. O’Donnell Huilin Li
author_facet	Zuanning Yuan Roxana Georgescu Grant D. Schauer Michael E. O’Donnell Huilin Li
author_sort	Zuanning Yuan
title	Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
title_short	Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
title_full	Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
title_fullStr	Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
title_full_unstemmed	Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
title_sort	structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bf5369f5dc0e4ac5973ac7d20dc7daaf
work_keys_str_mv	AT zuanningyuan structureofthepolymeraseeholoenzymeandatomicmodeloftheleadingstrandreplisome AT roxanageorgescu structureofthepolymeraseeholoenzymeandatomicmodeloftheleadingstrandreplisome AT grantdschauer structureofthepolymeraseeholoenzymeandatomicmodeloftheleadingstrandreplisome AT michaeleodonnell structureofthepolymeraseeholoenzymeandatomicmodeloftheleadingstrandreplisome AT huilinli structureofthepolymeraseeholoenzymeandatomicmodeloftheleadingstrandreplisome
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Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

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