<italic toggle="yes">In Vivo</italic>-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic <italic toggle="yes">penA</italic> Alleles That Confer Ceftriaxone Resistance in <italic toggle="yes">Neisseria gonorrhoeae</italic>
ABSTRACT Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduce...
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Autores principales: | , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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American Society for Microbiology
2018
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Acceso en línea: | https://doaj.org/article/bf5cc6746a2948e9876c44e5b14525ce |
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