<italic toggle="yes">In Vivo</italic>-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic <italic toggle="yes">penA</italic> Alleles That Confer Ceftriaxone Resistance in <italic toggle="yes">Neisseria gonorrhoeae</italic>

<italic toggle="yes">In Vivo</italic>-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic <italic toggle="yes">penA</italic> Alleles That Confer Ceftriaxone Resistance in <italic toggle="yes">Neisseria gonorrhoeae</italic>

ABSTRACT Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduce...

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Bibliographic Details
Main Authors: Leah R. Vincent, Samuel R. Kerr, Yang Tan, Joshua Tomberg, Erica L. Raterman, Julie C. Dunning Hotopp, Magnus Unemo, Robert A. Nicholas, Ann E. Jerse
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Neisseria gonorrhoeae
aconitase
antibiotic resistance
biological fitness
competitive index
Microbiology
QR1-502
Online Access:https://doaj.org/article/bf5cc6746a2948e9876c44e5b14525ce
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