Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries

Abstract Genome-wide CRISPR-based knockout (CRISPR-KO) screening is an emerging technique which enables systematic genetic analysis of a cellular or molecular phenotype in question. Continuous improvements, such as modifications to the guide RNA (gRNA) scaffold and the development of gRNA on-target...

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Autores principales: Swee Hoe Ong, Yilong Li, Hiroko Koike-Yusa, Kosuke Yusa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/bf61f265b7c34397b4f245df7adcb64e
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