Flavonoids as Antidiabetic Agents

Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabet...

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Autores principales:	Yana Cahyana, Tsani Adiyanti
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	antidiabetic flavonoids interactions of flavonoids starch digestion Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bf6a93d750b9428980581f821bc83936
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id	oai:doaj.org-article:bf6a93d750b9428980581f821bc83936
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spelling	oai:doaj.org-article:bf6a93d750b9428980581f821bc839362021-12-02T14:51:23ZFlavonoids as Antidiabetic Agents1411-94202460-157810.22146/ijc.58439https://doaj.org/article/bf6a93d750b9428980581f821bc839362021-02-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/58439https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. The aim of this review is to describe the flavonoid's ability as an alternative treatment for diabetes type-II patients. This paper addresses several aspects in which flavonoids may impart a pivotal role in starch digestion, such as the interaction of flavonoids with enzymes involved in starch hydrolysis, the role of flavonoids in inhibiting glucose absorption, as well as the interaction of flavonoids with starch to form a complex resistant to hydrolysis. Further studies, however, are suggested to extensively carry out, particularly the ones dealing with the intervention study using human volunteers to reveal the role of flavonoids in the real applications. The data on human intervention studies are still rare and can further be exploited using meta-analysis to have firmer results. Flavonoids in the food matrix are more realistic to perform to reveal the effect of interaction with other compounds, which may affect the mechanism of flavonoids interaction or their bioavailability.Yana CahyanaTsani AdiyantiDepartment of Chemistry, Universitas Gadjah Madaarticleantidiabeticflavonoidsinteractions of flavonoidsstarch digestionChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 2, Pp 512-526 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidiabetic flavonoids interactions of flavonoids starch digestion Chemistry QD1-999
spellingShingle	antidiabetic flavonoids interactions of flavonoids starch digestion Chemistry QD1-999 Yana Cahyana Tsani Adiyanti Flavonoids as Antidiabetic Agents
description	Flavonoids are polyphenol compounds that exert many potential health benefits, including diabetes type-II, which is the third most common disease that causes death, right after cancer and cardiovascular diseases. The excessively high level of blood glucose has been believed to trigger type II diabetes. The aim of this review is to describe the flavonoid's ability as an alternative treatment for diabetes type-II patients. This paper addresses several aspects in which flavonoids may impart a pivotal role in starch digestion, such as the interaction of flavonoids with enzymes involved in starch hydrolysis, the role of flavonoids in inhibiting glucose absorption, as well as the interaction of flavonoids with starch to form a complex resistant to hydrolysis. Further studies, however, are suggested to extensively carry out, particularly the ones dealing with the intervention study using human volunteers to reveal the role of flavonoids in the real applications. The data on human intervention studies are still rare and can further be exploited using meta-analysis to have firmer results. Flavonoids in the food matrix are more realistic to perform to reveal the effect of interaction with other compounds, which may affect the mechanism of flavonoids interaction or their bioavailability.
format	article
author	Yana Cahyana Tsani Adiyanti
author_facet	Yana Cahyana Tsani Adiyanti
author_sort	Yana Cahyana
title	Flavonoids as Antidiabetic Agents
title_short	Flavonoids as Antidiabetic Agents
title_full	Flavonoids as Antidiabetic Agents
title_fullStr	Flavonoids as Antidiabetic Agents
title_full_unstemmed	Flavonoids as Antidiabetic Agents
title_sort	flavonoids as antidiabetic agents
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/bf6a93d750b9428980581f821bc83936
work_keys_str_mv	AT yanacahyana flavonoidsasantidiabeticagents AT tsaniadiyanti flavonoidsasantidiabeticagents
_version_	1718389471857082368

Flavonoids as Antidiabetic Agents

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