Structural determinants and functional consequences of protein affinity for membrane rafts

Lipid rafts are plasma membrane domains that specifically recruit particular proteins. Here, the authors show that the surface area, length and palmitoylation of single-pass transmembrane domains are crucial for raft partitioning and propose a general model to predict protein association with rafts.

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Autores principales:	Joseph H. Lorent, Blanca Diaz-Rohrer, Xubo Lin, Kevin Spring, Alemayehu A. Gorfe, Kandice R. Levental, Ilya Levental
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf79ee15bd4e4f5e84037c1d3629d8d3
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spelling	oai:doaj.org-article:bf79ee15bd4e4f5e84037c1d3629d8d32021-12-02T17:06:07ZStructural determinants and functional consequences of protein affinity for membrane rafts10.1038/s41467-017-01328-32041-1723https://doaj.org/article/bf79ee15bd4e4f5e84037c1d3629d8d32017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01328-3https://doaj.org/toc/2041-1723Lipid rafts are plasma membrane domains that specifically recruit particular proteins. Here, the authors show that the surface area, length and palmitoylation of single-pass transmembrane domains are crucial for raft partitioning and propose a general model to predict protein association with rafts.Joseph H. LorentBlanca Diaz-RohrerXubo LinKevin SpringAlemayehu A. GorfeKandice R. LeventalIlya LeventalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph H. Lorent Blanca Diaz-Rohrer Xubo Lin Kevin Spring Alemayehu A. Gorfe Kandice R. Levental Ilya Levental Structural determinants and functional consequences of protein affinity for membrane rafts
description	Lipid rafts are plasma membrane domains that specifically recruit particular proteins. Here, the authors show that the surface area, length and palmitoylation of single-pass transmembrane domains are crucial for raft partitioning and propose a general model to predict protein association with rafts.
format	article
author	Joseph H. Lorent Blanca Diaz-Rohrer Xubo Lin Kevin Spring Alemayehu A. Gorfe Kandice R. Levental Ilya Levental
author_facet	Joseph H. Lorent Blanca Diaz-Rohrer Xubo Lin Kevin Spring Alemayehu A. Gorfe Kandice R. Levental Ilya Levental
author_sort	Joseph H. Lorent
title	Structural determinants and functional consequences of protein affinity for membrane rafts
title_short	Structural determinants and functional consequences of protein affinity for membrane rafts
title_full	Structural determinants and functional consequences of protein affinity for membrane rafts
title_fullStr	Structural determinants and functional consequences of protein affinity for membrane rafts
title_full_unstemmed	Structural determinants and functional consequences of protein affinity for membrane rafts
title_sort	structural determinants and functional consequences of protein affinity for membrane rafts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf79ee15bd4e4f5e84037c1d3629d8d3
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_version_	1718381754898710528

Structural determinants and functional consequences of protein affinity for membrane rafts

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