A dual molecular analogue tuner for dissecting protein function in mammalian cells

Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the l...

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Autores principales: Ran Brosh, Iryna Hrynyk, Jessalyn Shen, Avinash Waghray, Ning Zheng, Ihor R. Lemischka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/bf9049e062094f6ba57a70054e8f6541
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