A dual molecular analogue tuner for dissecting protein function in mammalian cells

Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the l...

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Autores principales:	Ran Brosh, Iryna Hrynyk, Jessalyn Shen, Avinash Waghray, Ning Zheng, Ihor R. Lemischka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf9049e062094f6ba57a70054e8f6541
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id	oai:doaj.org-article:bf9049e062094f6ba57a70054e8f6541
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spelling	oai:doaj.org-article:bf9049e062094f6ba57a70054e8f65412021-12-02T16:58:12ZA dual molecular analogue tuner for dissecting protein function in mammalian cells10.1038/ncomms117422041-1723https://doaj.org/article/bf9049e062094f6ba57a70054e8f65412016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11742https://doaj.org/toc/2041-1723Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the levels of two proteins and validate its application in stem cells.Ran BroshIryna HrynykJessalyn ShenAvinash WaghrayNing ZhengIhor R. LemischkaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ran Brosh Iryna Hrynyk Jessalyn Shen Avinash Waghray Ning Zheng Ihor R. Lemischka A dual molecular analogue tuner for dissecting protein function in mammalian cells
description	Loss-of-function approaches are fundamental for dissecting the roles played by genes but methods to simultaneously perturb several proteins in the same mammalian cell are scarce. Here the authors harness the plant auxin and jasmonate hormone-degradation pathways and RNAi technology, to control the levels of two proteins and validate its application in stem cells.
format	article
author	Ran Brosh Iryna Hrynyk Jessalyn Shen Avinash Waghray Ning Zheng Ihor R. Lemischka
author_facet	Ran Brosh Iryna Hrynyk Jessalyn Shen Avinash Waghray Ning Zheng Ihor R. Lemischka
author_sort	Ran Brosh
title	A dual molecular analogue tuner for dissecting protein function in mammalian cells
title_short	A dual molecular analogue tuner for dissecting protein function in mammalian cells
title_full	A dual molecular analogue tuner for dissecting protein function in mammalian cells
title_fullStr	A dual molecular analogue tuner for dissecting protein function in mammalian cells
title_full_unstemmed	A dual molecular analogue tuner for dissecting protein function in mammalian cells
title_sort	dual molecular analogue tuner for dissecting protein function in mammalian cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bf9049e062094f6ba57a70054e8f6541
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A dual molecular analogue tuner for dissecting protein function in mammalian cells

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