Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populations.

Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populations.

<h4>Background & aims</h4>Limited understanding of the role for specific macrophage subsets in the pathogenesis of cholestatic liver injury is a barrier to advancing medical therapy. Macrophages have previously been implicated in both the mal-adaptive and protective responses in obst...

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Main Authors: Sarah A Taylor, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Kyle D Gromer, Hiam Abdala-Valencia, Kiwon Nam, Salina T Dominguez, Anna B Montgomery, Paul A Reyfman, Lorena Ostilla, Joshua B Wechsler, Carla M Cuda, Richard M Green, Harris Perlman, Deborah R Winter
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c015eb78f3cb4aa88de1330263a1b31d
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https://doaj.org/article/c015eb78f3cb4aa88de1330263a1b31d

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