Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.

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Autores principales: Yun C. Chang, Ami Khanal Lamichhane, Hongyi Cai, Peter J. Walter, John E. Bennett, Kyung J. Kwon-Chung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c0165229b0b542f78f4b272e586dce76
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