Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.

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Autores principales:	Yun C. Chang, Ami Khanal Lamichhane, Hongyi Cai, Peter J. Walter, John E. Bennett, Kyung J. Kwon-Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0165229b0b542f78f4b272e586dce76
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spelling	oai:doaj.org-article:c0165229b0b542f78f4b272e586dce762021-12-02T17:30:39ZModerate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci10.1038/s41467-021-23745-12041-1723https://doaj.org/article/c0165229b0b542f78f4b272e586dce762021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23745-1https://doaj.org/toc/2041-1723Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.Yun C. ChangAmi Khanal LamichhaneHongyi CaiPeter J. WalterJohn E. BennettKyung J. Kwon-ChungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun C. Chang Ami Khanal Lamichhane Hongyi Cai Peter J. Walter John E. Bennett Kyung J. Kwon-Chung Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
description	Pathogenic fungi rapidly develop resistance to the antifungal agent 5-fluorocytosine (5-FC). Here, Chang et al. explore the mechanisms by which Cryptococcus develops 5-FC resistance at a high frequency, including mutations in several genes and altered levels of key metabolites.
format	article
author	Yun C. Chang Ami Khanal Lamichhane Hongyi Cai Peter J. Walter John E. Bennett Kyung J. Kwon-Chung
author_facet	Yun C. Chang Ami Khanal Lamichhane Hongyi Cai Peter J. Walter John E. Bennett Kyung J. Kwon-Chung
author_sort	Yun C. Chang
title	Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
title_short	Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
title_full	Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
title_fullStr	Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
title_full_unstemmed	Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
title_sort	moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0165229b0b542f78f4b272e586dce76
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Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

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