Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators

ABSTRACT Interferon (IFN) is required for protecting mice from viral pathogenesis; reciprocally, it mediates the deleterious septic shock response to bacterial infection. The critical transcription factor for IFN induction, in both cases, is IRF-3, which is activated by TLR3 or RIG-I signaling in re...

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Autores principales: Saurabh Chattopadhyay, Volker Fensterl, Ying Zhang, Manoj Veleeparambil, Jaime L. Wetzel, Ganes C. Sen
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2013
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Acceso en línea:https://doaj.org/article/c01906a0d1de483f9a7d3798980120bf
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