Variable number tandem repeats mediate the expression of proximal genes

Variable number tandem repeats mediate the expression of proximal genes

Variable number tandem repeats (VNTRs) are implicated in human diseases yet have been difficult to analyse computationally. Here, the authors describe a neural network method, adVNTR-NN, that allows rapid and accurate genotyping of VNTRs from large whole genome sequencing datasets.

Guardado en:
Detalles Bibliográficos
Autores principales: Mehrdad Bakhtiari, Jonghun Park, Yuan-Chun Ding, Sharona Shleizer-Burko, Susan L. Neuhausen, Bjarni V. Halldórsson, Kári Stefánsson, Melissa Gymrek, Vineet Bafna
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c0620434d6a14d2c97241fa0db512255
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c0620434d6a14d2c97241fa0db512255
record_format dspace
spelling oai:doaj.org-article:c0620434d6a14d2c97241fa0db5122552021-12-02T18:15:29ZVariable number tandem repeats mediate the expression of proximal genes10.1038/s41467-021-22206-z2041-1723https://doaj.org/article/c0620434d6a14d2c97241fa0db5122552021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22206-zhttps://doaj.org/toc/2041-1723Variable number tandem repeats (VNTRs) are implicated in human diseases yet have been difficult to analyse computationally. Here, the authors describe a neural network method, adVNTR-NN, that allows rapid and accurate genotyping of VNTRs from large whole genome sequencing datasets.Mehrdad BakhtiariJonghun ParkYuan-Chun DingSharona Shleizer-BurkoSusan L. NeuhausenBjarni V. HalldórssonKári StefánssonMelissa GymrekVineet BafnaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mehrdad Bakhtiari
Jonghun Park
Yuan-Chun Ding
Sharona Shleizer-Burko
Susan L. Neuhausen
Bjarni V. Halldórsson
Kári Stefánsson
Melissa Gymrek
Vineet Bafna
Variable number tandem repeats mediate the expression of proximal genes
description Variable number tandem repeats (VNTRs) are implicated in human diseases yet have been difficult to analyse computationally. Here, the authors describe a neural network method, adVNTR-NN, that allows rapid and accurate genotyping of VNTRs from large whole genome sequencing datasets.
format article
author Mehrdad Bakhtiari
Jonghun Park
Yuan-Chun Ding
Sharona Shleizer-Burko
Susan L. Neuhausen
Bjarni V. Halldórsson
Kári Stefánsson
Melissa Gymrek
Vineet Bafna
author_facet Mehrdad Bakhtiari
Jonghun Park
Yuan-Chun Ding
Sharona Shleizer-Burko
Susan L. Neuhausen
Bjarni V. Halldórsson
Kári Stefánsson
Melissa Gymrek
Vineet Bafna
author_sort Mehrdad Bakhtiari
title Variable number tandem repeats mediate the expression of proximal genes
title_short Variable number tandem repeats mediate the expression of proximal genes
title_full Variable number tandem repeats mediate the expression of proximal genes
title_fullStr Variable number tandem repeats mediate the expression of proximal genes
title_full_unstemmed Variable number tandem repeats mediate the expression of proximal genes
title_sort variable number tandem repeats mediate the expression of proximal genes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c0620434d6a14d2c97241fa0db512255
work_keys_str_mv AT mehrdadbakhtiari variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT jonghunpark variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT yuanchunding variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT sharonashleizerburko variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT susanlneuhausen variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT bjarnivhalldorsson variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT karistefansson variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT melissagymrek variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
AT vineetbafna variablenumbertandemrepeatsmediatetheexpressionofproximalgenes
_version_ 1718378418050957312

Ejemplares similares