Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesop...

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Main Authors: Yusuke Yamamoto, Xia Wang, Denis Bertrand, Florian Kern, Ting Zhang, Marcin Duleba, Supriya Srivastava, Chiea Chuen Khor, Yuanyu Hu, Lane H. Wilson, Hagen Blaszyk, Daniil Rolshud, Ming Teh, Jianjun Liu, Brooke E. Howitt, Matthew Vincent, Christopher P. Crum, Niranjan Nagarajan, Khek Yu Ho, Frank McKeon, Wa Xian
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/c0724ec3705f4b048002d0900b5ba0a1
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https://doaj.org/article/c0724ec3705f4b048002d0900b5ba0a1

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