Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion
Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesop...
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Nature Portfolio
2016
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oai:doaj.org-article:c0724ec3705f4b048002d0900b5ba0a12021-12-02T15:34:11ZMutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion10.1038/ncomms103802041-1723https://doaj.org/article/c0724ec3705f4b048002d0900b5ba0a12016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10380https://doaj.org/toc/2041-1723Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.Yusuke YamamotoXia WangDenis BertrandFlorian KernTing ZhangMarcin DulebaSupriya SrivastavaChiea Chuen KhorYuanyu HuLane H. WilsonHagen BlaszykDaniil RolshudMing TehJianjun LiuBrooke E. HowittMatthew VincentChristopher P. CrumNiranjan NagarajanKhek Yu HoFrank McKeonWa XianNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yusuke Yamamoto Xia Wang Denis Bertrand Florian Kern Ting Zhang Marcin Duleba Supriya Srivastava Chiea Chuen Khor Yuanyu Hu Lane H. Wilson Hagen Blaszyk Daniil Rolshud Ming Teh Jianjun Liu Brooke E. Howitt Matthew Vincent Christopher P. Crum Niranjan Nagarajan Khek Yu Ho Frank McKeon Wa Xian Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| description |
Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma. |
| format |
article |
| author |
Yusuke Yamamoto Xia Wang Denis Bertrand Florian Kern Ting Zhang Marcin Duleba Supriya Srivastava Chiea Chuen Khor Yuanyu Hu Lane H. Wilson Hagen Blaszyk Daniil Rolshud Ming Teh Jianjun Liu Brooke E. Howitt Matthew Vincent Christopher P. Crum Niranjan Nagarajan Khek Yu Ho Frank McKeon Wa Xian |
| author_facet |
Yusuke Yamamoto Xia Wang Denis Bertrand Florian Kern Ting Zhang Marcin Duleba Supriya Srivastava Chiea Chuen Khor Yuanyu Hu Lane H. Wilson Hagen Blaszyk Daniil Rolshud Ming Teh Jianjun Liu Brooke E. Howitt Matthew Vincent Christopher P. Crum Niranjan Nagarajan Khek Yu Ho Frank McKeon Wa Xian |
| author_sort |
Yusuke Yamamoto |
| title |
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| title_short |
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| title_full |
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| title_fullStr |
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| title_full_unstemmed |
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| title_sort |
mutational spectrum of barrett’s stem cells suggests paths to initiation of a precancerous lesion |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/c0724ec3705f4b048002d0900b5ba0a1 |
| work_keys_str_mv |
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