Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma

Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma

Abstract The 5-methylcytosines (5mC) have been implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). However, the role of 5-hydroxymethylcytosines (5hmC) that are generated from 5mC through active demethylation, in lymphomagenesis is unknown. We profil...

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Bibliographic Details
Main Authors: Brian C.-H. Chiu, Chang Chen, Qiancheng You, Rudyard Chiu, Girish Venkataraman, Chang Zeng, Zhou Zhang, Xiaolong Cui, Sonali M. Smith, Chuan He, Wei Zhang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Genetics
QH426-470
Online Access:https://doaj.org/article/c07415f9cf8248ff98fd82fcb6e0f829
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https://doaj.org/article/c07415f9cf8248ff98fd82fcb6e0f829

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