Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci

There is a need for analytical frameworks to investigate the evolution of complex genetic traits. Here, the authors develop an approach to simultaneously evaluate different evolutionary signatures on trait-associated genetic variants for complex traits and apply it to study spontaneous preterm birth...

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Autores principales: Abigail L. LaBella, Abin Abraham, Yakov Pichkar, Sarah L. Fong, Ge Zhang, Louis J. Muglia, Patrick Abbot, Antonis Rokas, John A. Capra
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c07ea25152944d9985c310b525f3f635
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