Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci

There is a need for analytical frameworks to investigate the evolution of complex genetic traits. Here, the authors develop an approach to simultaneously evaluate different evolutionary signatures on trait-associated genetic variants for complex traits and apply it to study spontaneous preterm birth...

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Autores principales:	Abigail L. LaBella, Abin Abraham, Yakov Pichkar, Sarah L. Fong, Ge Zhang, Louis J. Muglia, Patrick Abbot, Antonis Rokas, John A. Capra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c07ea25152944d9985c310b525f3f635
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spelling	oai:doaj.org-article:c07ea25152944d9985c310b525f3f6352021-12-02T16:17:53ZAccounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci10.1038/s41467-020-17258-62041-1723https://doaj.org/article/c07ea25152944d9985c310b525f3f6352020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17258-6https://doaj.org/toc/2041-1723There is a need for analytical frameworks to investigate the evolution of complex genetic traits. Here, the authors develop an approach to simultaneously evaluate different evolutionary signatures on trait-associated genetic variants for complex traits and apply it to study spontaneous preterm birth.Abigail L. LaBellaAbin AbrahamYakov PichkarSarah L. FongGe ZhangLouis J. MugliaPatrick AbbotAntonis RokasJohn A. CapraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abigail L. LaBella Abin Abraham Yakov Pichkar Sarah L. Fong Ge Zhang Louis J. Muglia Patrick Abbot Antonis Rokas John A. Capra Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
description	There is a need for analytical frameworks to investigate the evolution of complex genetic traits. Here, the authors develop an approach to simultaneously evaluate different evolutionary signatures on trait-associated genetic variants for complex traits and apply it to study spontaneous preterm birth.
format	article
author	Abigail L. LaBella Abin Abraham Yakov Pichkar Sarah L. Fong Ge Zhang Louis J. Muglia Patrick Abbot Antonis Rokas John A. Capra
author_facet	Abigail L. LaBella Abin Abraham Yakov Pichkar Sarah L. Fong Ge Zhang Louis J. Muglia Patrick Abbot Antonis Rokas John A. Capra
author_sort	Abigail L. LaBella
title	Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
title_short	Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
title_full	Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
title_fullStr	Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
title_full_unstemmed	Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
title_sort	accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c07ea25152944d9985c310b525f3f635
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Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci

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