Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.

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Autores principales: Patricia P. Centeno, Amanda Herberger, Hee-Chang Mun, Chialing Tu, Edward F. Nemeth, Wenhan Chang, Arthur D. Conigrave, Donald T. Ward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c08a3a761322408bb35d7a424c6b5065
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