Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.

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Autores principales:	Patricia P. Centeno, Amanda Herberger, Hee-Chang Mun, Chialing Tu, Edward F. Nemeth, Wenhan Chang, Arthur D. Conigrave, Donald T. Ward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c08a3a761322408bb35d7a424c6b5065
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spelling	oai:doaj.org-article:c08a3a761322408bb35d7a424c6b50652021-12-02T17:01:46ZPhosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion10.1038/s41467-019-12399-92041-1723https://doaj.org/article/c08a3a761322408bb35d7a424c6b50652019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12399-9https://doaj.org/toc/2041-1723Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.Patricia P. CentenoAmanda HerbergerHee-Chang MunChialing TuEdward F. NemethWenhan ChangArthur D. ConigraveDonald T. WardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia P. Centeno Amanda Herberger Hee-Chang Mun Chialing Tu Edward F. Nemeth Wenhan Chang Arthur D. Conigrave Donald T. Ward Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
description	Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.
format	article
author	Patricia P. Centeno Amanda Herberger Hee-Chang Mun Chialing Tu Edward F. Nemeth Wenhan Chang Arthur D. Conigrave Donald T. Ward
author_facet	Patricia P. Centeno Amanda Herberger Hee-Chang Mun Chialing Tu Edward F. Nemeth Wenhan Chang Arthur D. Conigrave Donald T. Ward
author_sort	Patricia P. Centeno
title	Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
title_short	Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
title_full	Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
title_fullStr	Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
title_full_unstemmed	Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
title_sort	phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c08a3a761322408bb35d7a424c6b5065
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Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

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