Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data.

Over the last decade the availability of SNP-trait associations from genome-wide association studies has led to an array of methods for performing Mendelian randomization studies using only summary statistics. A common feature of these methods, besides their intuitive simplicity, is the ability to c...

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Autores principales: Ciarrah Barry, Junxi Liu, Rebecca Richmond, Martin K Rutter, Deborah A Lawlor, Frank Dudbridge, Jack Bowden
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/c099838721364574958c3eb547906b95
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