Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes

Abstract Background The associations between serum free triiodothyronine (FT3) and diabetic peripheral neuropatprohy (DPN)/carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes are still unclear. The purpose of our study was to explore the relations of FT3 to DPN and carotid ath...

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Autores principales:	Mei-Fang Li, Jiang-Feng Ke, Shuai Li, Jun-Wei Wang, Zhi-Hui Zhu, Jing-Bo Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Free triiodothyronine Diabetic peripheral neuropathy Carotid atherosclerotic lesions Type 2 diabetes Euthyroid function Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c0a1d191fcb14b1894a916bcab878c3f
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spelling	oai:doaj.org-article:c0a1d191fcb14b1894a916bcab878c3f2021-12-05T12:24:19ZSerum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes10.1186/s13098-021-00760-21758-5996https://doaj.org/article/c0a1d191fcb14b1894a916bcab878c3f2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00760-2https://doaj.org/toc/1758-5996Abstract Background The associations between serum free triiodothyronine (FT3) and diabetic peripheral neuropatprohy (DPN)/carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes are still unclear. The purpose of our study was to explore the relations of FT3 to DPN and carotid atherosclerotic lesions in Chinese type 2 diabetes inpatients with euthyroid function. Methods 2477 euthyroid inpatients with type 2 diabetes were recruited and they were stratified into quartiles by FT3 levels in this cross-sectional study. Peripheral neuropathy was assessed by neurological symptoms and signs as well as nerve conduction velocity tests. Carotid atherosclerotic lesions, including carotid intima-media thickness, plaque and stenosis, were evaluated by Doppler ultrasound. Results The prevalence of DPN in type 2 diabetic patients exhibited the significant decrease across the FT3 quartiles (23.5%, 20.9%, 18.8%, and 11.2%, respectively, p < 0.001). Multiple logistical regression analysis also revealed that FT3 quartiles were significantly and inversely associated with DPN. Compared with the subjects in the highest FT3 quartile, the adjusted odds ratios (95% confidence interval) of DPN from the first to third FT3 quartile were successively 2.338 (1.407–3.884), 1.903 (1.134–3.194) and 1.598 (0.960–1.125). The patients with DPN had significantly higher prevalence of carotid atherosclerotic lesions compared with non-DPN patients. However, no statistical association was observed between FT3 quartiles and carotid atherosclerotic lesions after adjusting for confounder factors. Conclusions Lower FT3 within the normal range was independently associated with DPN, but not with carotid atherosclerotic lesions in Chinese euthyroid inpatients with type 2 diabetes.Mei-Fang LiJiang-Feng KeShuai LiJun-Wei WangZhi-Hui ZhuJing-Bo LiBMCarticleFree triiodothyronineDiabetic peripheral neuropathyCarotid atherosclerotic lesionsType 2 diabetesEuthyroid functionNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Free triiodothyronine Diabetic peripheral neuropathy Carotid atherosclerotic lesions Type 2 diabetes Euthyroid function Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Free triiodothyronine Diabetic peripheral neuropathy Carotid atherosclerotic lesions Type 2 diabetes Euthyroid function Nutritional diseases. Deficiency diseases RC620-627 Mei-Fang Li Jiang-Feng Ke Shuai Li Jun-Wei Wang Zhi-Hui Zhu Jing-Bo Li Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
description	Abstract Background The associations between serum free triiodothyronine (FT3) and diabetic peripheral neuropatprohy (DPN)/carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes are still unclear. The purpose of our study was to explore the relations of FT3 to DPN and carotid atherosclerotic lesions in Chinese type 2 diabetes inpatients with euthyroid function. Methods 2477 euthyroid inpatients with type 2 diabetes were recruited and they were stratified into quartiles by FT3 levels in this cross-sectional study. Peripheral neuropathy was assessed by neurological symptoms and signs as well as nerve conduction velocity tests. Carotid atherosclerotic lesions, including carotid intima-media thickness, plaque and stenosis, were evaluated by Doppler ultrasound. Results The prevalence of DPN in type 2 diabetic patients exhibited the significant decrease across the FT3 quartiles (23.5%, 20.9%, 18.8%, and 11.2%, respectively, p < 0.001). Multiple logistical regression analysis also revealed that FT3 quartiles were significantly and inversely associated with DPN. Compared with the subjects in the highest FT3 quartile, the adjusted odds ratios (95% confidence interval) of DPN from the first to third FT3 quartile were successively 2.338 (1.407–3.884), 1.903 (1.134–3.194) and 1.598 (0.960–1.125). The patients with DPN had significantly higher prevalence of carotid atherosclerotic lesions compared with non-DPN patients. However, no statistical association was observed between FT3 quartiles and carotid atherosclerotic lesions after adjusting for confounder factors. Conclusions Lower FT3 within the normal range was independently associated with DPN, but not with carotid atherosclerotic lesions in Chinese euthyroid inpatients with type 2 diabetes.
format	article
author	Mei-Fang Li Jiang-Feng Ke Shuai Li Jun-Wei Wang Zhi-Hui Zhu Jing-Bo Li
author_facet	Mei-Fang Li Jiang-Feng Ke Shuai Li Jun-Wei Wang Zhi-Hui Zhu Jing-Bo Li
author_sort	Mei-Fang Li
title	Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
title_short	Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
title_full	Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
title_fullStr	Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
title_full_unstemmed	Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
title_sort	serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c0a1d191fcb14b1894a916bcab878c3f
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Serum free triiodothyronine is inversely associated with diabetic peripheral neuropathy but not with carotid atherosclerotic lesions in euthyroid patients with type 2 diabetes

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