A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan...
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Nature Portfolio
2020
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oai:doaj.org-article:c0a8a14897d44e9db090036236f8b1ee2021-12-02T18:01:49ZA versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands10.1038/s41467-020-18907-62041-1723https://doaj.org/article/c0a8a14897d44e9db090036236f8b1ee2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18907-6https://doaj.org/toc/2041-1723Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan-binding proteins.Emily RodriguesJaesoo JungHeajin ParkCaleb LooSepideh SoukhtehzariElena N. KitovaFahima MozanehGour DaskhanEdward N. SchmidtVivian AghanyaSusmita SarkarLaura StreithChris D. St. LaurentLinh NguyenJean-Philippe JulienLori J. WestKarla C. WilliamsJohn S. KlassenMatthew S. MacauleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Emily Rodrigues Jaesoo Jung Heajin Park Caleb Loo Sepideh Soukhtehzari Elena N. Kitova Fahima Mozaneh Gour Daskhan Edward N. Schmidt Vivian Aghanya Susmita Sarkar Laura Streith Chris D. St. Laurent Linh Nguyen Jean-Philippe Julien Lori J. West Karla C. Williams John S. Klassen Matthew S. Macauley A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| description |
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan-binding proteins. |
| format |
article |
| author |
Emily Rodrigues Jaesoo Jung Heajin Park Caleb Loo Sepideh Soukhtehzari Elena N. Kitova Fahima Mozaneh Gour Daskhan Edward N. Schmidt Vivian Aghanya Susmita Sarkar Laura Streith Chris D. St. Laurent Linh Nguyen Jean-Philippe Julien Lori J. West Karla C. Williams John S. Klassen Matthew S. Macauley |
| author_facet |
Emily Rodrigues Jaesoo Jung Heajin Park Caleb Loo Sepideh Soukhtehzari Elena N. Kitova Fahima Mozaneh Gour Daskhan Edward N. Schmidt Vivian Aghanya Susmita Sarkar Laura Streith Chris D. St. Laurent Linh Nguyen Jean-Philippe Julien Lori J. West Karla C. Williams John S. Klassen Matthew S. Macauley |
| author_sort |
Emily Rodrigues |
| title |
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| title_short |
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| title_full |
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| title_fullStr |
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| title_full_unstemmed |
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| title_sort |
versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c0a8a14897d44e9db090036236f8b1ee |
| work_keys_str_mv |
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