Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.
Asparagine synthetase (AS) catalyzes the ATP-dependent conversion of aspartate into asparagine using ammonia or glutamine as nitrogen source. There are two distinct types of AS, asparagine synthetase A (AS-A), known as strictly ammonia-dependent, and asparagine synthetase B (AS-B), which can use eit...
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Autores principales: | , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Public Library of Science (PLoS)
2013
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Acceso en línea: | https://doaj.org/article/c0ab720a2516465d9ac83aeaad32d3fa |
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