Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system

Abstract Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme. It is known that CYP3A4 is the dominant drug...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Moe Ichikawa, Hiroki Akamine, Michika Murata, Sumito Ito, Kazuo Takayama, Hiroyuki Mizuguchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/c0b45f99dce54b83a6c5de5e16934232
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!