L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.

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Bibliographic Details
Main Authors: Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu, Johanna Ivaska
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a
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