Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastas...

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Autores principales: Noel P. Fusté, Rita Fernández-Hernández, Tània Cemeli, Cristina Mirantes, Neus Pedraza, Marta Rafel, Jordi Torres-Rosell, Neus Colomina, Francisco Ferrezuelo, Xavier Dolcet, Eloi Garí
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
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