Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastas...

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Autores principales:	Noel P. Fusté, Rita Fernández-Hernández, Tània Cemeli, Cristina Mirantes, Neus Pedraza, Marta Rafel, Jordi Torres-Rosell, Neus Colomina, Francisco Ferrezuelo, Xavier Dolcet, Eloi Garí
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
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spelling	oai:doaj.org-article:c0e1a19ad0024a3ea991a7fbf199db912021-12-02T14:39:51ZCytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin10.1038/ncomms115812041-1723https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db912016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11581https://doaj.org/toc/2041-1723Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis.Noel P. FustéRita Fernández-HernándezTània CemeliCristina MirantesNeus PedrazaMarta RafelJordi Torres-RosellNeus ColominaFrancisco FerrezueloXavier DolcetEloi GaríNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
description	Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis.
format	article
author	Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí
author_facet	Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí
author_sort	Noel P. Fusté
title	Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_short	Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_full	Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_fullStr	Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_full_unstemmed	Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_sort	cytoplasmic cyclin d1 regulates cell invasion and metastasis through the phosphorylation of paxillin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
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Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

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