Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastas...

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Autores principales: Noel P. Fusté, Rita Fernández-Hernández, Tània Cemeli, Cristina Mirantes, Neus Pedraza, Marta Rafel, Jordi Torres-Rosell, Neus Colomina, Francisco Ferrezuelo, Xavier Dolcet, Eloi Garí
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
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spelling oai:doaj.org-article:c0e1a19ad0024a3ea991a7fbf199db912021-12-02T14:39:51ZCytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin10.1038/ncomms115812041-1723https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db912016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11581https://doaj.org/toc/2041-1723Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis.Noel P. FustéRita Fernández-HernándezTània CemeliCristina MirantesNeus PedrazaMarta RafelJordi Torres-RosellNeus ColominaFrancisco FerrezueloXavier DolcetEloi GaríNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Noel P. Fusté
Rita Fernández-Hernández
Tània Cemeli
Cristina Mirantes
Neus Pedraza
Marta Rafel
Jordi Torres-Rosell
Neus Colomina
Francisco Ferrezuelo
Xavier Dolcet
Eloi Garí
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
description Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis.
format article
author Noel P. Fusté
Rita Fernández-Hernández
Tània Cemeli
Cristina Mirantes
Neus Pedraza
Marta Rafel
Jordi Torres-Rosell
Neus Colomina
Francisco Ferrezuelo
Xavier Dolcet
Eloi Garí
author_facet Noel P. Fusté
Rita Fernández-Hernández
Tània Cemeli
Cristina Mirantes
Neus Pedraza
Marta Rafel
Jordi Torres-Rosell
Neus Colomina
Francisco Ferrezuelo
Xavier Dolcet
Eloi Garí
author_sort Noel P. Fusté
title Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_short Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_full Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_fullStr Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_full_unstemmed Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
title_sort cytoplasmic cyclin d1 regulates cell invasion and metastasis through the phosphorylation of paxillin
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91
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