Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastas...
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Nature Portfolio
2016
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oai:doaj.org-article:c0e1a19ad0024a3ea991a7fbf199db912021-12-02T14:39:51ZCytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin10.1038/ncomms115812041-1723https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db912016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11581https://doaj.org/toc/2041-1723Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis.Noel P. FustéRita Fernández-HernándezTània CemeliCristina MirantesNeus PedrazaMarta RafelJordi Torres-RosellNeus ColominaFrancisco FerrezueloXavier DolcetEloi GaríNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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Science Q |
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Science Q Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
description |
Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastasis. |
format |
article |
author |
Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí |
author_facet |
Noel P. Fusté Rita Fernández-Hernández Tània Cemeli Cristina Mirantes Neus Pedraza Marta Rafel Jordi Torres-Rosell Neus Colomina Francisco Ferrezuelo Xavier Dolcet Eloi Garí |
author_sort |
Noel P. Fusté |
title |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
title_short |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
title_full |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
title_fullStr |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
title_full_unstemmed |
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
title_sort |
cytoplasmic cyclin d1 regulates cell invasion and metastasis through the phosphorylation of paxillin |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91 |
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