Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al. show that Cyclin D1/Cdk4 phosphorylates paxillin and thereby promotes cellular migration and metastas...
Enregistré dans:
Auteurs principaux: | Noel P. Fusté, Rita Fernández-Hernández, Tània Cemeli, Cristina Mirantes, Neus Pedraza, Marta Rafel, Jordi Torres-Rosell, Neus Colomina, Francisco Ferrezuelo, Xavier Dolcet, Eloi Garí |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2016
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/c0e1a19ad0024a3ea991a7fbf199db91 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss
par: Panfeng Fu, et autres
Publié: (2021) -
p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
par: Talha Anwar, et autres
Publié: (2018) -
Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.
par: Grzegorz Sarek, et autres
Publié: (2010) -
Photosynthetic control of Arabidopsis leaf cytoplasmic translation initiation by protein phosphorylation.
par: Edouard Boex-Fontvieille, et autres
Publié: (2013) -
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
par: Smruthi Vijayaraghavan, et autres
Publié: (2017)