Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

Current treatments for chronic hepatitis B virus (HBV) infection are not curative. Here, the authors show that an antifungal drug, ciclopirox, inhibits HBV capsid assembly and synergizes with nucleoside/nucleotide analogs to prevent HBV replication in cells and in a humanized liver mouse model.

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Autores principales:	Jung-Ah Kang, Songwon Kim, Minji Park, Hyun-Jin Park, Jeong-Hyun Kim, Sanghyeok Park, Jeong-Ryul Hwang, Yong-Chul Kim, Yoon Jun Kim, Yuri Cho, Mi Sun Jin, Sung-Gyoo Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c10c1a7e6f104a508eca916208b6abe6
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spelling	oai:doaj.org-article:c10c1a7e6f104a508eca916208b6abe62021-12-02T14:40:16ZCiclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly10.1038/s41467-019-10200-52041-1723https://doaj.org/article/c10c1a7e6f104a508eca916208b6abe62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10200-5https://doaj.org/toc/2041-1723Current treatments for chronic hepatitis B virus (HBV) infection are not curative. Here, the authors show that an antifungal drug, ciclopirox, inhibits HBV capsid assembly and synergizes with nucleoside/nucleotide analogs to prevent HBV replication in cells and in a humanized liver mouse model.Jung-Ah KangSongwon KimMinji ParkHyun-Jin ParkJeong-Hyun KimSanghyeok ParkJeong-Ryul HwangYong-Chul KimYoon Jun KimYuri ChoMi Sun JinSung-Gyoo ParkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Ah Kang Songwon Kim Minji Park Hyun-Jin Park Jeong-Hyun Kim Sanghyeok Park Jeong-Ryul Hwang Yong-Chul Kim Yoon Jun Kim Yuri Cho Mi Sun Jin Sung-Gyoo Park Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
description	Current treatments for chronic hepatitis B virus (HBV) infection are not curative. Here, the authors show that an antifungal drug, ciclopirox, inhibits HBV capsid assembly and synergizes with nucleoside/nucleotide analogs to prevent HBV replication in cells and in a humanized liver mouse model.
format	article
author	Jung-Ah Kang Songwon Kim Minji Park Hyun-Jin Park Jeong-Hyun Kim Sanghyeok Park Jeong-Ryul Hwang Yong-Chul Kim Yoon Jun Kim Yuri Cho Mi Sun Jin Sung-Gyoo Park
author_facet	Jung-Ah Kang Songwon Kim Minji Park Hyun-Jin Park Jeong-Hyun Kim Sanghyeok Park Jeong-Ryul Hwang Yong-Chul Kim Yoon Jun Kim Yuri Cho Mi Sun Jin Sung-Gyoo Park
author_sort	Jung-Ah Kang
title	Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
title_short	Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
title_full	Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
title_fullStr	Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
title_full_unstemmed	Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly
title_sort	ciclopirox inhibits hepatitis b virus secretion by blocking capsid assembly
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c10c1a7e6f104a508eca916208b6abe6
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Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

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